I just downloaded and unzipped doomsday_2.2.2_x64.zip. Immediately after unzipping this file my Norton 360 virus app popped up with a threat message. It says that doomsday-server.exe contains the threat "WS_Reputation.1" and Norton removed it from my computer. I had installed doomsday_2.2.1_x64.zip about a week and a half ago and this virus threat did not appear. This might be something you should be aware of.
So I deleted this folder and downloaded doomsday_2.2.2_x64.msi and ran it. I got no warnings and everything seems to be working fine.